A regional health innovation hackathon hosted in partnership with Siriraj Hospital in Bangkok, Thailand, gathering over 200 innovators from across Southeast Asia. The event challenged multidisciplinary teams over three days to tackle complex regional issues related to chronic diseases and mental health. The structure included the InterSystems GenAI Challenge, a special collaboration that mandated the integration of Generative AI into prototypes to enhance solution effectiveness and intelligence, reinforcing the strategic focus on applied AI development.